Gru, a criminal mastermind, adopts three orphans as pawns to carry out the biggest heist in history. His life takes an unexpected turn when the little girls see the evildoer as their potential father.

When Gru, the world's most super-bad turned super-dad has been recruited by a team of officials to stop lethal muscle and a host of Gru's own, he has to fight back with new gadgetry, cars, and more minion madness.

Gru meets his long-lost, charming, cheerful, and more successful twin brother Dru, who wants to team up with him for one last criminal heist.